Fernblock (PLE Polypodium leucotomos) has proven antioxidant properties with oral and topical photoprotector activity. Fernblock is an organic extract derived from the fern polypodium leucotomos, indigenous to Central and South America. The extract has extensive preclinical and clinical data supporting its safety and efficacy, and is registered with the U.S. FDA for both human and veterinary use.
The product is patented and currently registered in Europe, Asia, and the Americas. It is the active ingredient in a pharmaceutical and OTC formulation known as a photo immune enhancer. Fernblock is distributed in over 26 countries as PPL-240™, Difur, and Heliocare.
Key Technology Benefits & Features
With its antioxidant and photoprotector properties, Fernblock increases the skin’s tolerance to sunburn and reduces sunburned cells and the effects of aging on the skin.
Properties & Therapeutic Activities
The global antioxidant effect was quantified chemically and previously confirmed with biological tests, showing significant results when compared to vitamin C and beta-carotene.
Administered orally or topically, it increases tolerance to sunburn. In studies conducted in conjunction with the Dermatology Department at Harvard University (Boston, MA, U.S.), it was found that oral intake prior to exposure to the sun significantly increased the minimum amount of solar erythema, resulting in a protection factor of approximately 2.5.
DNA or genetic material protector
Oral use of EPL prior to exposure to ultraviolet radiation significantly reduced the number of cells with thymine dimmers. After use, a significant reduction in the number of sunburned cells was observed.
The oral administration of EPL modulates the production of buffers and cytokines proinflammatories by the skin cells after their exposure to ultraviolet radiation. EPL has also shown protective capabilities in Langerhans cells, maintaining their numbers and morphology.
This benefit has been experimentally confirmed in a murine model for aging skin, showing a reduction of skin elastosis compared to general elastosis. It is a naturally-derived organic extract.